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Hello Steve,
AxCrypt will encrypt any file that “looks like a file in a folder” on your computer. This is how most apps work with files. Very few have direct support for specific providers. For cloud service providers, this is typically done by synchronizing the cloud storage with a “mirror” folder on your computer. AxCrypt will happily encrypt those files, in the synchronized local copy. These will then become synchronized with the cloud and all is well.